Human platelet-specific antigen, Siba, is associated with the molecular weight polymorphism of glycoprotein Ib alpha
نویسندگان
چکیده
منابع مشابه
Human platelet-specific antigen, Siba, is associated with the molecular weight polymorphism of glycoprotein Ib alpha.
Platelet-specific antigen Sib(a) has been highly implicated in the pathogenesis of refractoriness to human leukocyte antigen (HLA)-matched platelet transfusions in Japan. We provide evidence that the Sib(a) antigen is located on the glycoprotein (GP) Ib alpha and has a close association with the molecular weight (mol wt) polymorphism of GPIb. In modified antigen-capture ELISA (MACE), anti-Sib(a...
متن کاملmolecular weight polymorphism of glycoprotein Ib alpha Human platelet
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متن کاملHuman Platelet-Specific Antigen, Sib", Is Associated With the Molecular Weight Polymorphism
Platelet-specific antigen Sib' has been highly implicated in the pathogenesis of refractoriness to human leukocyte antigen (HLA)-matched platelet transfusions in Japan. We provide evidence that the Sib' antigen is located on the glycoprotein (GP) Iba and has a close association with the molecular weight (mol wt) polymorphism of GPlb. In modified antigencapture ELISA (MACE), anti-Sib' antibody r...
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Background: Asthma is recognized as a common cause of disability, of great economic cost, and of preventable deaths. In this study we aimed to test our hypothesis to evaluate the relationship between the Human Platelet Antigen-1(HPA-1) polymorphism and bronchial asthma and its severity, which would suggest genetic variances that may be responsible for expression or activation of these receptors...
متن کاملLocalization of the platelet-specific HPA-2 (Ko) alloantigens on the N-terminal globular fragment of platelet glycoprotein Ib alpha.
The human platelet-specific alloantigens HPA-2a and HPA-2b (= Kob and Koa) together constitute a biallelic antigen system. The HPA-2 antigens have not, to date, been located on a particular platelet membrane molecule. Here, we describe the localization of these antigens on platelet glycoprotein (GP) Ib alpha. Platelets from two patients with the Bernard-Soulier syndrome (BSS) were HPA-2(a-,b-) ...
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ژورنال
عنوان ژورنال: Blood
سال: 1991
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v78.7.1722.1722